Quantitative Resolution to some 'Absolute Discrepancies' in Cancer Theories: a View from Phage lambda Genetic Switch

摘要

Is it possible to understand cancer? Or more specifically, is it possible tounderstand cancer from genetic side? There already many answers in literature.The most optimistic one has claimed that it is mission-possible. Duesberg andhis colleagues reviewed the impressive amount of research results on canceraccumulated over 100 years. It confirms the a general opinion that consideringall available experimental results and clinical observations there is no cancertheory without major difficulties, including the prevailing gene-based cancertheories. They have then listed 9 "absolute discrepancies" for such cancertheory. In this letter the quantitative evidence against one of their majorreasons for dismissing mutation cancer theory, by both in vivo experiment and afirst principle computation, is explicitly pointed out.